Polymorphisms of GSTT1 and M1 Genotypes and Their Effects on Elevated Aflatoxin Exposure and Increased Risk of Hepatocellular Carcinoma

Genotypes of GSTT1 and M1 were determined by PCR, and the level of aflatoxin B1-albumin adduots in serum samples was examined by ELISA in HCC patients and healthy controls recruited in three case-control studies, conducted in Hebei, Jiangsu and Guangxi, China. It was found that compared with those with non-null genotypes of both GSTT1 and M1, the odds ratios of developing HCC for those with null genotype of GSTT1 and null genotypes of both GSTT1 and M1 were 2.34(95%CI 1.01～5.46) and 3.43(95%CI 1.50～7.91), respectivly. It was also found that Astatistlcally significant biological gradient between serum level of AFBalbumin adducts and risk of HCC. These findings imply That Genotypes of GSTT1and M1 and AFB-HSA may be employed in screening the persons at risk of HCC.