A Relative Study on the Expression of PCNAand c-myc in Esophageal Squamous Cell Carcinoma
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Graphical Abstract
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Abstract
The expression of PCNA and c-myc oncoprotein in cases of esophageal squa-mous cell carcinoma (ESCC) and the epithelia adjacent to ESCC were observed with LSAB immunohistochemical techniques.The results showed that the carcinoma cells revealed a positive immunoreaction to both factors in different degree cases of the epithelia adjacent to the ESCC were PCNA-positive,but only two of them with displasia showed c-myc protein-positive.The ratio of positive cell to both factors in group of ESCC with lymphonodi-metastasis were significantly higher than that of the other group with non mphonodi-metastasis·There was a good positive relationship between the expression of cmyc and that of PCNA.cmyc oncogeneand PCNA might play an important role in the carcinogenosis of esophageal epitheli.
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