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Song YuanZong, . Inhibitive Effect of Genistein on the OxidativeDamage to Guanine Studied by CGC/MS[J]. Cancer Research on Prevention and Treatment, 1997, 24(3): 142-145.
Citation: Song YuanZong, . Inhibitive Effect of Genistein on the OxidativeDamage to Guanine Studied by CGC/MS[J]. Cancer Research on Prevention and Treatment, 1997, 24(3): 142-145.
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Inhibitive Effect of Genistein on the OxidativeDamage to Guanine Studied by CGC/MS

  • Institute of medical Biochemistry, Guangdong Medical College, Zhanjiang, 524023

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  • Institztte of medical Biochemistry，Gzcangdong Medical College, Zhanjiang,Genistein is a isoflavone with antioxidant property and antitumor activity.hydroxyguanine is a sensitive marker for the oxidative damage to DNA，and a well-estabilished biomarker relevant to carcinogenesis and aging as well .To study the relationship between the antioxidant property of genistein and its antitumor activi-ty，in this paper，the effect of genistein on the damage to guanine induced by Fen-ton reaction 2O2+Fe2+·OH+OH-+Fe3+)was studied using capillary gas chromatography/mass spectrometry. The results show that genistein can inhibit the formation of hydroxyguanine potently，and at a concentration of 60y.mol·Lgenistein can reduce the production of 8-hydroxyguanine to of that in control，which suggest that the inhibitive effect of genistein onH2O2 induced DNA damage maybe implicated in its antitumor ctivity.Based on this paper and other studies，it is suggested that this inhibitive effect of genistein results from the scavenging ofH2O2 by genistein.
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  • 1. JMessing MJ，Persky V,Setchel KDR,et al.Soy in-take and cancer risk: a review of in vitro and in vivodata.Nutr Cancer,1994，21:113一131.
    2. Jha HC,Von RG and Zilliken F.Inhibition of in vitromicrosomal lipid peroxidation by isoflavonoids.Biochem Pharmacol,1985.34:1367一1369.
    3. Ames BN and Gold LS.Endogenous mutagens and thecause of aging and cancer.Mutat Res.1991，250，3一16.宋元宗，庄海旗.张海涛.等.Fez+存在时Hz0:对鸟嗦A令的氧化作用.广东医学院学报，1996,14(4)，312一314.
    4. 宋元宗，庄海旗.祝其锋，等.鸟嗓吟碱基氧化损伤产物经基鸟嗦吟的CGC/MS检测.自由基生命科学进 678展，1996,4，145一149.
    5. 贾之慎，邻建敏，唐孟成.比色法测定Fenton反应产生的经自由基.生物化学与生物物理进展，1996,23(2):184一186.
    6. Wei H,Cai Q,and Rahn RU.Inhibition of UV light-and Fenton reaction-induced oxidative DNA damage bythe' soybean isoflavone genistein.Carcinogenesis,1996,17(1):73一77.
    7. Floyd RA.The role of hydroxydeoxyguanosine incarcinogenesis.Carcinogenesis,1990.11(9):1447一1450.
    8. Uckun FM,Evans WE,Forsyth CJ,et al.Biotherapy of B-cell precusor leukemia by targeting genistein to CD associated tyrosine kinases.Science,1995,267 :886一891.
    9. Yamashita Y,Kawada S,and Nakano H.Induction of mammalian topoisomerase I -dependent DNA cleav-age by none-intercalative flavonoids,genistein and orobol.Bioehem Pharmaeol,1990,39:737一744.
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