Pathoiogic Study on effect of Acanthopanax Santicosus Polysaccharides and GST during rats hepatocarcinogenesis

The effect of Acanthopanax Santicosus polysaccharides(ASPS)and Glutathione S-transferase(GST)for hepatic cellular morphology, the number of Y-GIu-tamyl transpeptiase(Y-GT) positive cells and Y-GT tissue content were studed in 148 rat livers based on 3'-me-DAB hepatocarcinogenesis. Results show:1, In APSP group, hepatomorphology are similar to 3'-me-DAB group and the number of Y-GT positive cells and Y-GT content of hepatic tissue slowly increase, with a lower proliferatic level than in 3'-me-DAB group;In Apsp group, 9 day after experimenl show pathologic Variety, but in 3'-me-DAB group 4 day;These data demonstrate ASPS have distinct retardant effect to neoplastic proliferation 2, pathomorphology in GST group are also similar with 3'-me-DAB group, and the number of Y-GT poshive cells and Y-GT content indictate higher proliferatic level than 3'-me-DAB group.It suggestes the effect of hepatic detoxication in GST is suspected by appling subcutaneous immunomethod.Influnce on experimental hepatocarcinoma in ASPS make further study, incrensing ASPS dose be suggested.