Malignancy Grading and Quantitative Histomorphologic Diagnosis of Giant Cell Tumor of Bone

51 cases of giant cell tumor of bone(GCT) were studied using image analysis technology(IAT),while 13 cases of bone eyst and 15 cases of osteosarcoma were served as eontrol groups.DNA content of the tumorous nuclei(GCT:stromal cell nuelei) was measured in all cases.Their relevant DNA Ploid Patterns were determined.Additionally,the relationships between DNA ploidy with postoperational recurrence of GCT and its conventional grading were evaluated.Statistical analysis on above four aspects showed that there was no significant difference between GCTof grade Ⅰand Ⅱ,and both of there biological properties fell within the categories of potential maligmant and low-grade malignant lesions.The results also indicated that the GCT patient with DNA SC percentage above 10% should be regarded as the high-risk case who is likely to have recurrence and metastasis.