Study on express of α-HCG and α-HCGmRNA in pancreatic endocrine tumors using immunohistochemistry and in situ PCR

The antigent Alpha-subunit of human chorionic gonadompin(α-HCG)and α-HCGmRNA in pacreatic endocrine tumors(PET)were investigated by immunoh-istochemistry and in situ PCR.It was found that α-HCG and α-HCGmRNA can be detected in PET buy not in normal islet cells.α-HCG immunoreacti-vity was expressed by 5 of 28(17.9%)in benign PET and 14 of 24(58.3%) in malignant PET.Using in situ PCR of α-HCGmRNA,a strong signal in PET was obtained.The clinicopathological sighficance of α-HCG in PET was discussed.