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Yu Jiyao, . Study on express of α-HCG and α-HCGmRNA in pancreatic endocrine tumors using immunohistochemistry and in situ PCR[J]. Cancer Research on Prevention and Treatment, 1998, 25(5): 367-369.
Citation: Yu Jiyao, . Study on express of α-HCG and α-HCGmRNA in pancreatic endocrine tumors using immunohistochemistry and in situ PCR[J]. Cancer Research on Prevention and Treatment, 1998, 25(5): 367-369.
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Study on express of α-HCG and α-HCGmRNA in pancreatic endocrine tumors using immunohistochemistry and in situ PCR

  • General hospital of the Navy,Beijing 100037

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  • The antigent Alpha-subunit of human chorionic gonadompin(α-HCG)and α-HCGmRNA in pacreatic endocrine tumors(PET)were investigated by immunoh-istochemistry and in situ PCR.It was found that α-HCG and α-HCGmRNA can be detected in PET buy not in normal islet cells.α-HCG immunoreacti-vity was expressed by 5 of 28(17.9%)in benign PET and 14 of 24(58.3%) in malignant PET.Using in situ PCR of α-HCGmRNA,a strong signal in PET was obtained.The clinicopathological sighficance of α-HCG in PET was discussed.
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    • References (6)
  • 1. Heitz PU,Kasper M,Kloppel G,Polak JM,Vaitukaitis JL.Glycoproteinhormone alpha-chain production by pancreatic endocrine tumors:a specific marker for maligruancy.Immunurytochemical analysis of tumors of 155 patients.Cancer,1983,51:277.
    2. Kehn CR,Roscn SW,Weintraub BD,Fajans S S,Gorden P.Ectopic produnction of chrionic gradotropin and its subunits by islet-cell tumors.A specific marker for malignancy.N Engl Jed, 1997:297.
    3. Graeme-Cook F,Nardi G,Compton C.Immunocychemical staining for huamn choeionic gonadotropin subunits does not predict maligna-ncy in insulinomas.Am Jcli Pathol,1990,93:373.
    4. Azzcni C,Comintti-Maggioni M,Bordi C,Viale G.In situhybridization of α-HCGmRNA in routi-nely fixed tissued.Pathol Res Pract,1993,189:64.
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    6. Ruschoff J,Wilemer S,Brevel M,Trautmann ME,Falmer M,Amold R,Kloppel G.Nucleolar organizer regions and glycoproteinhorm-one α-chain reaction as markers of maligrancy in endocrine tumours of the pancreas.Histopathology,1993,22:51
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