The Relationship of Blood Vessel and Lymphatic Vessel invasion to Prognosis in Stage Ⅰ、Ⅱ Resected Nonsmall Cell Lung Cancer

In order to assess the prognostic value of blood vessel and lymphatic vessel invasion(BVI and LVI) in stage Ⅰ、Ⅱ resected nonsmall cell lung cancer.76 resected patientsfrom stage Ⅰ and Ⅱ NSCLC were followed.BVI and LVI were evaluated by light microscope in hematoxylin stain slides.Association among variables were tested by the Pearson chi-square test.Sue vival were analyzed by kaplan-Meier product-limit methodand the multivariable Cox model.The pattens' mean age was 56±8.2 years.Medianfollow-up was 5l months.Overall 3-year survival was 68% and overall 5-year sruvivalwas 64%.BVlwas present in 28% of NSCLC cases and LVI in 0.70%.BVI(＋)/or LVI(＋) was present in 34% of NSCLC.In univariate analysis, BVI ut not LVI was associated with poor survival (x²= 8.66, p=0.003).Cox regression multivariate analysisshowed vessel invasion(p=0.003) and lymph node status (p=0.01) were independentpredictors for poor overall survival.Our study suggested that vessel invasion was important pathological factor in evaluating prognosis of stage Ⅰand Ⅱ NSCLC.