Study on Antitumor Activity of Bleomycin A6 and Pingyangmycin against Colorectal Cancer
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Graphical Abstract
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Abstract
Effect on antitumor activity of bleomycin A6 (A6)and pingyangmycin (PYM)against colorectal cancer was observed with human tumor cloning assay for sensitivity testing, transplantablemurine colon cancer 26 and human colon cancer HT-29 xenograftin nude mice.A6 and PYMshowed cytotoxicity for human colorectal cells.On the basis of equitoxic dose (l/gLD50),A6 andPYM exerted much stronger growth inhibition than mitomycin C(MMC) and 5-fluorouracil(5 FU) against murine colon cancer 26 both implanted subcutaneously and cecally.On subcutaneoustumor in duplicate experiments, the inhibition rates were 87% and 88%by A6, 97% and 91%byPYM, 64% and 25%byMMC, 46% and 27%bys-Fu.On cecaltrumor, the inhibition rates were99% and 97% by A6, 97%and 100% by PYM, 77% and 25% by MMC,44% by 5-Fu,respectively.At a 1/9LD50 equitoxic dose, A6 and PYM also exertedmuch stronger growth inhibitionagainst human colon cancer HT-29 xenograft in nude mice than MMC and 5-Fu.More extensive necrosis was found in tumors treated with A6 and PYM than those with MMC and 5 Fu.These observations indicate that A6 and PYM are potent antitumor agents against colorectalcancer.
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