Cytotoxic effect on the gastric cancer,colon cancer and ovary cancer of the carboplatin mixture liquid interaction with cellular DNA

The cytotoxic effect through interaction with celluar DNA of the carboplatin mixture liquid on the cell lines of gastric cancer(NKM-25),Colon cancer(HT-20) and ovary cancer(OVCA) were studied. There were no significantly changes in the high pentetration capacities of carboplatin into the tumour cells between carboplatin mixture liquid and carboplatin liquid. The formed platinum-DNA adducts were demonstrated no significant differences between the group of carboplatin mixture liquid and group carboplatin liquid (P＜0.05).It seems that the carboplatin mixture liquid fit the intraperitoneal chemotherapy for intraabdomonal malignacies more safely and effectively after surgical resection.