Antitumor Activity of Tumor cell vaccine with BCG and Its Induction of ApoPtosis inTumor Cells

The tumor bearing mice were injected id with S180 tumor cellvaccine (soluble tumor antigens) and BCG. The tumor growth was inhibited and the cytotoxicity of CTLwas increased. Both showed significant (P<0.01 ) difference than that of control groupor alone treatment group (tumor cell vaccine or BCG). The angment was much more significant when treatment was used in 6 days previously. Ultrastructure and floW cytometry showed in treatment group tumor tissue cell, the morphological change of apoptosisare comprises nuclear and cytoplasmic condensation. Content frequency histograms all cycle analysis revealed that the feature of apoptoic cell were observed in treatment group P<0.01. The results suggested the inducement of an apoptotic proceed in murine S180tumor cells which were treated by tumor cell vaccine with BCG during tumor regression.