The Synergistic Effect of Tumor Necrosis Factor andButhionone Sulfoximine on Ovarian Cancer

Objective: To study synergistic effect of Tumor Necrosis Factor (TNF) Combined with different concentration Buthionone Sulfoximine (BSO) on ovarian cancer Methods: 3AO and AO Ovarian neoplasms cell lines were used as target in vito.TNFBSO or TNF combined with BSO was utilized respectively to test killer ratio. Resuls: If different concentration BSO and TNF were used respectively,3AO Ovarian cancer cells couldn't be killed.The killer ratio against AO Ovarian cancer cells was 3849% (P005) with TNF(500/ml).The killer ratio against 3AO ovarian cancer cells was 459% (P001) with TNF (5000/ml) plus BSO (50g/ml) and 759% (P001) aginst AO. Conclution: Utilization of TNF combining with BSO is superior to that of respective TNF and BSO.