Expression of P 16 Protein in Renal Cell Carcinoma ( RCC )

Immunohistochemistry detection of P16 expression was carried out in 41 cases of renal carcinoma,in 18 normal renal tissue adjacent to neoplastic lesions and in 10 normal renal tissue.The positive rates of P16 was higher in normal renal tissue(89.3%)than in tumor tissue(58.5%)(P<0.05),and correlated with grading、staging and prognosis of patients,with no significant difference between clear renal cell carcinoma and granular cell carcinona.The results suggested that P16 played a critical role in the genesis and development of RCC and could be used as predictor of diagnosis and prognosis of renal carcinoma.