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Value of Serum CA-50 Measurementin Patients with Carcinoma of Digetive System[J]. Cancer Research on Prevention and Treatment, 1999, 26(6): 414-416.
Citation: Value of Serum CA-50 Measurementin Patients with Carcinoma of Digetive System[J]. Cancer Research on Prevention and Treatment, 1999, 26(6): 414-416.
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Value of Serum CA-50 Measurementin Patients with Carcinoma of Digetive System

  • Affiliated Hospital of Qingdao Medical College,Qingdao 266003

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  • Objective To evaluate the diagnosis value of contents of serum and asocitic CA-50 in the cases with carcinomatous ascites. Methods The serum CA-50 content was measured by radioimmunoassay in 54 normal individuals,176 patients with carcinoma of digestive system and 160 patients with benign diseases. Results The normal value was 3.80+2.45Ku/L The content of serum CA-50 in patients with carcinoma were much higher than those of healthy people and patients with benign diseases(P＜0.001 in both),and this occurred in the early stage and became even more obverious in the late stage.Taking the normal mean value plus two times of standard deviation as positive,the positive rate was 85.8% for carcinoma of digestive system.There was only two positive in 52 normals with a fales positive rate of 3.7%. Conclusion The detection of both esrum CA-50 and ascitic CA-50 may have a certain clinical prectical value in carcinoma of the digestive system diognosis,differential diagnosis and the monitor, prediction of prognosis.
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  • 1 Holmgeen Fi[, et al. Detection切monoclonal antibody of carbohydrate antigen CA50 in serum of patient with carcinoma. Br Med J. 1984, 288: 1479
    2 Paganuia M, et al. Clinical evaluation of CA-50 in seare of patients with diferent tumors. In: Holmgraen U.Tumor, marker antigens. LLnd, Sweden: student literature,1985,134
    3 陈智周.糖类抗原CASOF放射免疫抑制试验在肿瘤诊断和监测中的初步应用.中华肿瘤杂志,1987;9(6):435
    4 Hanmmarstrom S. Chemistry and immunology of CEA, C.4199 and CA-50. 1n: Holmgreen EJ,ed.Tumor, marker, antigens. Irrnd, Sweden:student Iiferature,1985.32:49
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