Relationship of Human Papillomavirus and P53 with Colorectal Carcinoma

Objective To assess the relationship of human papillomavirus(HPV)and p53 with colorectal carcinoma. Methods The 33 adenocarcinomas and 15 normal mucosal samples were selected for the current study using polymerase chain reaction(PCR) and immunohistochemical techniques. Results HPV DNA was detected in 9 of 33(27.27%)carcinomas;The expression of P53 protein was found in 18 of 33(54.55%)carcinomas;No HPV DNA and P53 expression were detected in all 15 normal colorectal specimens.Out of the 9 HPV DNA positive cases,only 3 cases with p53 protein expression were found. Conclusion HPV might be involved in the pathogenesis of colorectal carcinomas (P<0.05).HPV infection and p53 mutation may play a role independently in the carcinogenesis of colorectal cancer.