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LIU Zhong-cheng, DONG Xin-shu, WANG Dong-hua. Expression Of P21, P53 In Rectal Cancer And Clinical Significance[J]. Cancer Research on Prevention and Treatment, 1999, 26(4): 281-283.
Citation: LIU Zhong-cheng, DONG Xin-shu, WANG Dong-hua. Expression Of P21, P53 In Rectal Cancer And Clinical Significance[J]. Cancer Research on Prevention and Treatment, 1999, 26(4): 281-283.
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Expression Of P21, P53 In Rectal Cancer And Clinical Significance

  • Department of General Surgery, the Zhongshan Hospital of Xiamen 361004

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  • Objective: to study the expression of P21.P53 in rectal cancer and its relation to clinical pathological characteristics and the significance of its prognosing rectal cancer. Methods: Using immunohistochemistry (s-p method) P21.P53 were studied in 110 cases of rectal the expression of cancer, using normal rectum as controlling group. Results the positive rate of P21.P53 oncoprotein was 54.5 %、42.7 %, the expression of P53 had no relation to clinical pathological characteristics of rectal cancer, the cases with expressing P21 oncoprotein had lower 3 or 5 year survival rate, worsely differentiated, higher rate of lymph metastasis. Conclusion: P53 gene might be related to rectal. carcinogenisis, P21 might be prognosis of rectalcancer.
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