The Research of the Relation between the Gene Mutation of P⁵³ and Prognosis in Pediatric Non-Hodgkin Lymphoma

Objective: To explore the relation between the Gene Mutation of P⁵³ and Prognosis in pediatric Non-Hodgkin Lymphoma. Methods: To detect the 5 -6 exon of P⁵³ gene in 31 Ⅱ-Ⅲ phases pediatric Non-Hodgkin Lymphoma patients by PCR-SSCP technique and follow-up study them for 8 years. Results: The gene mutation of P53were found in 11 children (11/31)and the recurrecewere observed in 7 of them. The recurrece was only observed in 1 patient of 20 children without gene mutation of P⁵³. Conclusion: The gene mutation of P⁵³ is one of the indicators of prognosis in pediatric Non-Hodgkin Lymphoma and is related with recurrence in early stage.