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SUN Shen-rong, LI Zhi-hua, TU Yi, LIU Xue-feng. The Research of the Relation between the Gene Mutation of P53 and Prognosis in Pediatric Non-Hodgkin Lymphoma[J]. Cancer Research on Prevention and Treatment, 1999, 26(4): 270-271.
Citation: SUN Shen-rong, LI Zhi-hua, TU Yi, LIU Xue-feng. The Research of the Relation between the Gene Mutation of P53 and Prognosis in Pediatric Non-Hodgkin Lymphoma[J]. Cancer Research on Prevention and Treatment, 1999, 26(4): 270-271.
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The Research of the Relation between the Gene Mutation of P53 and Prognosis in Pediatric Non-Hodgkin Lymphoma

  • General Surgery Department, The first Affiliated Hospital of Hubei Medical University, Wuhan 430060

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  • Objective: To explore the relation between the Gene Mutation of P53 and Prognosis in pediatric Non-Hodgkin Lymphoma. Methods: To detect the 5 -6 exon of P53 gene in 31 Ⅱ-Ⅲ phases pediatric Non-Hodgkin Lymphoma patients by PCR-SSCP technique and follow-up study them for 8 years. Results: The gene mutation of P53were found in 11 children (11/31)and the recurrecewere observed in 7 of them. The recurrece was only observed in 1 patient of 20 children without gene mutation of P53. Conclusion: The gene mutation of P53 is one of the indicators of prognosis in pediatric Non-Hodgkin Lymphoma and is related with recurrence in early stage.
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