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BAO Jian-zhong, ZHENG Jian-ming, ZHOU Lin, NI Can-rong, ZHANG Chun-cai. Expression of p21 、p185 、EGFR 、LN and Type IV Collagen in Human Osteosarcoma Tissue[J]. Cancer Research on Prevention and Treatment, 1999, 26(4): 265-267.
Citation: BAO Jian-zhong, ZHENG Jian-ming, ZHOU Lin, NI Can-rong, ZHANG Chun-cai. Expression of p21 、p185 、EGFR 、LN and Type IV Collagen in Human Osteosarcoma Tissue[J]. Cancer Research on Prevention and Treatment, 1999, 26(4): 265-267.
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Expression of p21 、p185 、EGFR 、LN and Type IV Collagen in Human Osteosarcoma Tissue

  • Department of pathology in the second military medical university, Shanghai 200433

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  • Objective: To evaluate the significance of p21, p185, EGFR protein expression and LN, type IV collagen in human osteosarcoma . Methods: p21, p185, EGFR protein expression and LN, type IV collagen were examined in 40 cases human osteosarcoma tissue with immunohistochemical ABC methods. Results: Accumulation of p21 protein was found in 8 out of 38 cases osteosarcomas. The positive rates of p185 andEGFR were respectively 65.8 % and 50.0 %. It was observed that the majority of LN and type IV collagen expression in osteosarcoma was defective. Conclusion: The results of p21, p185 and EGFR high expression in human osteosarcoma suggest that they did have a correlation with osteosarcoma origin and development; The changes of LN and type IV collagen have significant effect on osteosarcoma invade and metastasis.
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