Prognostic Correlation of HER2 Over2expressions in Breast Cancer

Objective 　To research the correlations between HER2 overexpression and other prognostic fac2 tors that are assessed in clinical practice and the influence on prognosis of HER2 overexpression with breast cancer. Methods 　The authors evaluated HER2 status in 176 surgical specimens of patient s with breast cancer in Tongji Hospital f rom J an. 2002 to Dec. 2003, and correlations were evaluated with the other prognostic factors. And the prognosis was compared between the HER2 overexpeession and nega2 tive expression. Results 　HER2 overexpression was negative correlated with ER status ( P = 0. 031) and PR status ( P = 0. 002), while not correlated with the other prognostic factors . Multivariate analysis showed that HER2 is an independent prognostic factor for DFS ( P = 0. 018) . Conclusion 　HER2 overex2 pression may be considered a independent prognostic marker and directed in the t reatment in primary breast cancer.