In Vitro Effects of Indomethacin on Antitumor Immunity in Patients with Bladder Cancer
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Graphical Abstract
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Abstract
Objective To investigate the combined effects of interleukin 2 (IL 2) with either indomethacin (IM) on the proliferation and cytolysis of bladder tumor cells by lymphokine activated killer(LAK) cells in patients with bladder cancer. Methods LAK cell proliferation was assayed in the presence of various concentrations of IM by cell counting.Bladder cancer cell lines BIU 87,EJ and bladder tumor cells (BTC) from the patients were cultured as target cells,and the cytotoxicity of LAK cells was determined by 3...
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