Study on the correlation between c -erbB -2 amplification and mdr -1 expression in breast cancer

Objective To investigate the c-erbB-2 amplification and the mdr-1 expression in primary breast cancer and to reveal the correlation between these two genes. Methods PCR and RT-PCR was used respectively to examine the c-erbB-2 amplification and mdr-1 expression in 47 primary breast cancer. Results (1) The c-erbB-2 amplification was significantly linked to histological grade and the axillary lymph node involvement. Statistically significant difference in c-erbB-2 amplification was observed not o...