Antitumor effect of novobiocin on patients primary liver cancer cells

Objective To study the antitumor effect of novobiocin(NOVO) on patients primary liver cancer cells, and the modulation of NOVO on some clinical antitumor drugs. Methods Using antitumor agent sensitive assay(MTT method),the inhibiting effects of NOVO and five antitumor agents(MMC, 5-FU, DDP,CTX, ADM)on patients primary liver cancer cells were assayed, and the inhibiting effects of NOVO combining with one of the antitumor agents were also assayed respectively. Results NOVO had antitumor effect on patients pri...