The effects of COX-2 expression on vascular endothelial growth factor and angiogenesis in gastric carcinoma

Objective To investigate the effects of COX-2 expression on vascular endothelial growth factor (VEGF) and angiogenesis in gastric carcinoma. Methods The expression of COX-2, VEGF and microvascular density (MVD) was examined by immunohistochemical staining. Results COX-2 expression was detected in 62.2% of gastric carcinoma;The expression of COX-2 was significantly correlated with VEGF ( P <0.01);Increased expression of COX-2 and VEGF was significantly correlated with an increase in MVD ( P <...