Expression and Significance of p65 and Vascular Endothelial Growth Factor in Squamous Cell Carcinomas of Gingiva

Objective 　To investigate the expression of p65 and vascular endothelial growth factor (VEGF) in squamous cell carcinomas of gingiva ( GSCC) . Methods 　SP immunohistochemistry was used to determine the expression of p65 and VEGF in 46 GSCC tissues. Results 　The positive rate of p65 in GSCC was 63. 04 %, while the positive rate of VEGF was 56. 52 %. p65 was not correlated with pathological stage and lymphatic metastasis, but VEGF was correlated with that p65 was closely correlated with chinical stage ( P < 0. 05) . There was a positive correlation between the expression of p65 and VEGF in GSCC tissues ( P < 0. 05) . Conclusion 　p65 is associated with VEGF in GSCC, and can serve as a biomarker for the potentialities of invasion and metastasis of GSCC.