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LIN Shao qiang, YIN Xiao jing, LI Jun wu, LI Yang qiu, DING Yan qing. A Study of Antisense-Oligonucleotides in Down-Regulation of α2,6-Sialylation of Daudi Cells[J]. Cancer Research on Prevention and Treatment, 2004, 31(06): 338-340. DOI: 10.3971/j.issn.1000-8578.890
Citation: LIN Shao qiang, YIN Xiao jing, LI Jun wu, LI Yang qiu, DING Yan qing. A Study of Antisense-Oligonucleotides in Down-Regulation of α2,6-Sialylation of Daudi Cells[J]. Cancer Research on Prevention and Treatment, 2004, 31(06): 338-340. DOI: 10.3971/j.issn.1000-8578.890
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A Study of Antisense-Oligonucleotides in Down-Regulation of α2,6-Sialylation of Daudi Cells

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  • Objective To study the antisense oligonucleotides (antisense ODN) in down regulation of α2,6 sialyltransferase (ST6Gal I) activity and α2,6 sialylation of cell surface of Burkitt s lymphoma cell line Daudi. Methods Daudi cells were treated with modified antisense ODN in vitro, the ST6Gal I mRNA expression was examined by RT PCR, the ST6Gal I enzyme activity was measured with fluorometric sialyltransferase assay and the amount of α2,6 sialylation of cell surface was determined by FACS analysis.Resul...
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