The Inhibiting Effect of Radiation and Anti-VEGF Monoclonal Antibody on the Growth of Human Hepatocellular Carcinoma Xenografts

Objective To investigate the inhibiting effects of combining radiotherapy(RT) with anti-vascular endothelial growth factor(VEGF) monoclonal antibody(mAb) therapy on the growth of human SMMC-7721 hepatocellular carcinoma(HCC) xenografts in vivo. Methods HCC cell line was implanted s.c.in mice.All the mice with xenografts were divided into four groups,RT plus mAb group,RT group,mAb group and control group.Anti-VEGF mAb was injected i.p.on alternate days for a total of six injections at a dosage of 50μg each mo...