Effect of p16 Gene on the Apoptosis of Bladder Carcinoma Cells

Objective In order to investigate the effect of p16 gene on bladder carcinoma apoptosis. Methods 51 cases bladder carcinomas were studied by immunohistochemical (IHC) technique,while flow cytometry were used for apoptosis test.Result The positive rate of p16 was 47.1%(24/51).The average percentage of apoptosis cells were 1.5%,the percentage of apoptosis cells in p16 positive tumor tissue was 62.5% (more than 1.5%),the percentage of apoptosis cells in p16 negative tumor tissue were 25.9% (more than 1.5%),there were significant difference between positive and negative groups. Conclusion The expression of p16 was related with bladder tumor cell apoptosis,p16 gene may take part in positive-regulation of bladder tumour cell apoptosis.