Relationships between VEGF,MMP-7 and Biological Behaviors in Colorectal Carcinoma

Objective 　To explore the relationship s between VEGF, MMP-7 expression and progress, prognosis of colorectal Carcinoma. Methods 　SP immunohistochemical staining was used to examine expressions of VEGF, MMP-7 among 81 cases of colorectal carcinoma paraffin2embedded specimens. Rank sum test was used to analyze the expressions of VEGF, MMP-7. Results 　The expression of VEGF in colorectal carcinoma was positively correlated with depth of invasion ( P < 0. 01), lymph node metastasis ( P < 0. 01), distant metastasis ( P < 0. 01), Dukes stage. MMP-7 expression in colorectal carcinoma was also positively correlated with lymph node metastasis ( P < 0. 05), distant metastasis ( P < 0. 01), Dukes'stage. Expression of MMP-7 in mucous group was higher than that in high differentiation group ( P <0. 01) . The MMP-7 expression in patient s aged below 60y was st ronger than that in over 60y and 60y ( P< 0. 05) . Positive relationship appeared between VEGE and MMP-7. Conclusion 　VEGF, MMP-7 may improve the growth and metastasis of colorectal carcinoma. They could be prognostic factor of colorectal carcinoma. Decreasing the expression and activity of VEGF and MMP-7 might be a new pathway for the treatment of colorectal carcinoma.