Analyses of Chemotherapy in Treatment of 98 Patients with Small Cell Lung Cancer

Objective 　To evaluate the efficacy, toxicity and side effects of CE(CBP 、VP-16 ), CAP(CTX 、EPI、DDP) and CE - CAP alternation in the t reatment of patient s with small cell lung cancer ( SCLC) . Methods 　A total of 98 patient s with SCLC diagnosed by pathology were treated with CE, CAP or CECAP regimen for 4 cycles. Results 　The overall response rates of the groups (CE, CAP or CE-CAP) were 84. 8 %、80. 4 % and 81 %respectively, there was no significant difference in the group s. The major toxicity and side effects were bone marrow inhibition and gastrointestinal reaction. Neut ropenia appeared 10. 8 % in CE group, 10. 8 % in CAP and 9. 5 % in CE-CAP group. The difference of hematologic toxicity in the three groups was no significant . Nausea and vomiting occurred 13 % in CE group, 25. 8 % in CAP group, 23. 8 % in CE2CAP group, there was statistically significant difference in the CE group and other two groups, but no significant difference in CAP group and CE-CAP group . Conclusion 　CE, CAP and CE-CAP are the effective regimen in the t reatment of patient s with small cell lung cancer (SCLC) . The difference of the response rates in the three groups is not significant . But there was less toxicity in CE group.