Expression of Cell Keratin in Malignant Melanoma

Objective 　To detect the expression and significance of cell keratin (CK) in malignant melanoma. Methods 　To detect CK、Vimentin、S2100 、HMB45 in 18 cases of malignant melanoma using immuno-histochemical method-PV-9000 two steps. Results 　The positive expression rates of CK in 18 cases of malignant melanoma were 67%(12/18) ;among them, the positive rates of CK and Vimentin in 16 cases of primary melanoma were 63 %(10/ 16), 100 %(16/ 16) respectively ; the positive rates CK and S-100 、CK and HMB₄₅ were 50 %(8/ 16) respectively, the positive expression rate of the above four kinds of antibodies was 44 %(7/ 16) ; the positive expression rates of the four kinds of antibodies in two cases of metastatic melanoma were 100 %(2/ 2) . Conclusion 　There was positive expression in varying degrees of CK in primary and metastasis melanoma.