The Count of Mast Cell (MC) and Tumor-Associated Macrophage ( TAM) and Cl inicopathologic Signif icance in Human Laryngneal Squamous Cell Carcinoma Tissues

Objective 　To study on the count s of MC and TAM and detect their clinicopathologic significances and relationship in human laryngneal squamous cell carcinoma tissues. Methods 　SP immunohistochemical method was used for the count s of MC and TAM on the routinely paraffin-embedded sections of surgical operated specimens of 41 cases with laryngneal squamous cell carcinoma. Results 　The count mean of MC and TAM was 19. 73 ±5. 50/ HP and 25. 95 ±7. 39/ HP, respectively. The count means of MC and TAM were significantly lower in the cases of aged ≤60 years, histologic grade I, without-metastasis of lymph node, and clinical stage T1 than that in the ones of aged > 60 years, histologic grade III, with-metastasis of lymph node and clinical stage T3 ( P < 0. 05 or P < 0. 01) . The close positive correlation was found between the count of MC and TAM. Conclusion 　The count of MC or/ and TAM might be important factor in reflecting the progression, biological behaviors and prognosis evaluating of the laryngneal squmous cell carcinoma.