Abnormality of Conf iguration of Microvessel in Hepatocellular Carcinoma

Objective 　To investigate the abnormality of configuration of microvessel in hepatocellular carcinoma ( HCC) . Methods 　Expressions of CD34 and Endoglin were studied through immunohistochemistry in fifty-six cases of HCC and their paraneoplastic liver tissue and six cases of normal liver tissue. The ultramicrost ructure of microvessel was observed using transmission elect ron microscope. Results 　Microvessel density (MVD) denoted by CD34 and Endoglin were 127. 1 ±5. 9 and 64. 6 ±11. 1 respectively in HCC, cont rasted with 7. 1 ±1. 3 and 6. 1 ±1. 2 in paraneoplastic liver tissue ( P < 0. 01) . The structure of microvessel was loose and the permeability increased in HCC. Microthrombi formed in the microvessel in HCC. Conclusion 　There was a large amount of st ructurally defect microvessel in HCC, which provided route for cancer metastasis.