Experimental Study of Reversal of Mutidrug Resistance by Cyclosporin Ain Various Human Gliom Cell Lines

Objective To explore the effects and mechanisms of reversing action on multidrug resistance by cyclosporin A in vitro in various human glioma cell lines overexpressing MDR 1 and MRP. Methods By the method of Rediolabeled oxorubicin,the human gliom cell lines were used to investigate the potential differences in the accumulation and efflux of antitumor drugs before and after the use of cyclosporin A. Results The accumulation of intracellular antitumor drug increased obvously after the use of cycosporin A in ...