PCR-SSCP Analysis of FADD Gene Mutation in Non-small Cell Lung Cancer

Objective This report aimed at the mutation of FADD gene in human non-small cell lung cancer, and the evaluation of its possible effect and mechanism on the development of NSCLC. Methods PCR-SSCP was used to detect FADD gene mutation in 74 specimens from primary site of NSCLC tissues and 13 samples of normal adjacent lung tissues. Results Altogether there were 5 cases of FADD gene mutation, and the analysis revealed that its mutation was positively correlated to the status of lymph node metastasis (r_ s= 0....