Dynamic Observation Microstructure of the Human Hepatic Carcinoma Cells Infected Bluetongue Virus HbC_3 Strain

Objective The cytobiological mechanism of BTV-HbC_ 3 killed the tumor cells were investigated in this study. Methods The morphogenesis and the pathological changes of the Hep-3B cells infected Bluetongue virus were studied by transmission electron microscope. Results BTV-HbC_ 3 were penetrated into cell with pinocytpsis. Viral outside capsid were hydrolated with hydrolase in the lysosome, which become subvirual particles. The viral inclubodies and subviral particles without outer layer proteins were observe...