The Correlation between IGF1,IGF2 Expression and Lymph Node Metastasis in Non-small Cell Lung Cancer

Objective To investigate the expression of insulin-like growth factors (IGF1 and IGF2, or IGFs) in non-small cell lung cancer (NSCLC) as well as the correlation between IGFs expression and regional lymph node metastasis. Methods The expression of IGF1 and IGF2 was investigated in 65 specimens from patients with NSCLC (29 cases contained normal lung tissue adjacent to cancer) and in 19 specimens from patients with benign lung diseases by immunohistochemistry and western blotting. Results IGF1 and IGF2 were o...