Immunoh istochem ica l Expression of A-ca ten in in Colorectal Cancer and Its Relations with Biological Behaviors of the Tumor

ObjectiveTo investigate expression of α-catenin in colorectal adenocarcinomas and its relationship with differentiation,depth of local invasiveness,lymph node metastasis and Dukes stage of the tumor. Methods α-catenin expression was evaluated immunohistochemically in 58 paraffin-embeded colorectal carcinoma and 10 normal colon mucosa specimens. Results In 58.6% (34/58) of the tumors,reduced α-catenin immunoreactivities were detected and were associated with loss of differenciation,lymph node metastasis an...