KDR mRNA Expression and its Clinical Significance in Human Non-Small Cell Lung Cancer

Objective To investigate the correlation between expression level of vascular endothelial growth factor receptor-2(KDR) and the microvessel density(MVD) and biological behavior of non-small cell lung cancer(NSCLC) and its prognosis. Methods KDR mRNA and MVD expression in 62 cases of NSCLC and 16 cases of benign pulmonary lesions were tested with in situ hybridization and immunohistochemistry methods, respectively. Results (1) significant differences in MVD and KDR mRNA expression weer found between NSCLC an...