The Enhanced Effect of Heparanase Gene Expression on the Invasive Ability of Colorectal Cancer Transformed Cell

Objective This study was invested the effects of heparanase gene on the invasive ability of colorectal cancer cells. Methods Heparanase gene was transfected to human colorectal cancer cell lines HT29. The cell growth kinetics and the ability of invading in vitro were detected by MTT and invading chamber. Tumorigencity and orthotopic implantation of histologically intact tumor in nude mice s ileocecal junction indicated the invasive ability of colorectal cancer transformed cell by the exogenous expression of...