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WANG Rui, WANG Rui-lin, FAN Qing-xia, WANG Liu-xing, LU Shi-xin, MA Wang, ZHAO Pei-rong. Insulin-induced Enhancement of Chemotherapeutic Response of 5-Fluorouracil and Its Mechanism[J]. Cancer Research on Prevention and Treatment, 2006, 33(04): 258-261. DOI: 10.3971/j.issn.1000-8578.3385
Citation: WANG Rui, WANG Rui-lin, FAN Qing-xia, WANG Liu-xing, LU Shi-xin, MA Wang, ZHAO Pei-rong. Insulin-induced Enhancement of Chemotherapeutic Response of 5-Fluorouracil and Its Mechanism[J]. Cancer Research on Prevention and Treatment, 2006, 33(04): 258-261. DOI: 10.3971/j.issn.1000-8578.3385
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Insulin-induced Enhancement of Chemotherapeutic Response of 5-Fluorouracil and Its Mechanism

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  • Objective To observe whether insulin can induce an enhancement of chemotherapeutic response of 5-fluorouracil (5-Fu) on human transplantable esophageal cancer nude model and study the mechanism of action. Methods The expression of cyclin D_1 in tumor tissue was tested by immunohistochemistry. Murine serum insulin-like growth factor1(IGF-1) and insulin-like growth factor binding protein3(IGFBP-3) were determined by ELISA. Results High, medium and low dose insulin ( 0.09, 0.06, 0.03 u/20g) combined with 5-F...
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