COX-2 and bcl-2 Expression and Their Relations to the Behavior of Nasopharyngeal Carcinoma
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Graphical Abstract
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Abstract
Objective To study the expression of cyclooxygenase-2 ( COX-2 ) and bcl-2 in nasopharyngeal carcinoma(NPC) and their relations to the clinicopathological features. Methods COX-2 and bcl-2 protein expression in 86 cases of nasopharyngeal carcinoma was examined by using immunohistochemical staining.All cases had been followed up 5 years. Results The overexpression rate of COX-2 in NPC was 73.3% (63/86) and it was correlated to primary tumor stage,lymph node metastasis,pathological grade,clinicopathological stag...
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