Expression and Significance of DDIT3 in Benign and Malignant Follicular Thyroid Tumors

Objective 　To investigate the expression and significance of DNA damage2inducible t ranscript 3 (DDIT3) in benign and malignant follicular thyroid tumors. Methods 　The expression of DDIT3 in 24 ca2 ses of follicular thyroid adenoma ( FTA) and 44 cases of follicular thyroid carcinoma ( FTC) was detected by immunohistochemist rical Envision method. Results 　The positive rates for DDIT3 in FTA and FTC were 20. 8 % and 93. 2 % respectively, there was significant difference between them ( P < 0. 001) . More2 over, 10 cases of paracarcinomatous tissue were observed, there was no or week expression of DDIT3. Conclusion 　DDIT3 may be used as a marker for differentiating FTC and FTA.