Short-term Effects of Nedaplatin Plus Futraful Chemotherapy in Treatment of Advanced Esophageal Carcinoma

Objective 　To observe the efficacy and the side effect s of nedaplatin with fut raful in the t reat2 ment of advanced esophageal carcinoma. Methods 　Observing group NDP/ FT2207 regiment : given neda2 platin 80～100 mg/ m2 on day 1and fut raful 500～600 mg/ m2 on day 1 to 5 ; cont rol group :DDP/ 52Fu reg2 iment received cisplatin 80～100 mg/ m2 on day 1and 52Fluorouracil 500～750 mg/ m2 on day 1 to 5. In both groups per 28 days was a cycle, 2～3 cycles were one course. Results 　Response and toxicity could be assessed in all the 78 patient s, 42 patient s were in observing group, the other 36 patiest s were in con2 t rol group. The response rate of patient s t reated by NDP/ FT2207 and DDP/ 52Fu were 57. 1 % (24/ 42) and 50 % (18/ 36) respectively. The two groups have no significant difference. Conclusion 　The side effect s as gast rointestinal reactions and myelosuppression etal in observing group is lighter than that in cont rol group.