Factor Expression with Hepatic Metastasis of Large Intestinal Carcinoma

Objective To study relation of mutant p53 and vasvular endothelial growth factor(VEGF) expression with hepatic metastasis f large intestinal carcinoma. Methods PCR-SSCP and DNA seqencing techniques were used to detect p53 mutation and VEGF was examined with RT-PCR in primary foci,paratumoral tissues and hepatic metastasis of 64 cases of colorectal cancer. Results In 64 cases the mutant rates of p53 in primary foci、paratumoral tissues and hepatic metastasis were 65.6%,9.1%,87.1% respectively.In Hepatic metas...