Effect of Gastric Juice on Bcl-2/Bax Expression of Human Bladder Cancer Cell Line
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Graphical Abstract
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Abstract
Objective To study the mechanism of apoptosis induced by gastric juice. Methods Flow cytometry and immunohistochemistry were utilized to observe the effect of gastric juice on Bcl-2/Bax expression of human bladder cancer cell line BIU-87. Results After administration of gastric juice,AI increased,Bcl-2 expression reduce,Bax expression increased and Bcl-2/Bax ratio was 0.71. Conclusion It was suggested that gastric juice could induce the apoptosis of BIU-87 by reducing Bcl-2 and increasing Bax.
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