Association about Trichomonas, HR-HPV Infection and Cervical Carcinoma

Objective 　To investigate whether the presence of trichomonas can increase the risk of having high-risk human papillomavirus ( HR-HPV) infection and cervical carcinoma. Methods 　All subjects were examined by liquid-based cytology and HR-HPV DNA test s. Of them, some negative cytological diagnosis caces and the cases of cytological diagnosis ≥atypical squamous cells (ASC) or HPV DNA positive were taken colposcopic biopsy. The presence of trichomonas was recorded in the cytological diagnosis. We compared the presence rates of Trichomonas in grades of cytological diagnoses, grades of histological diagnosis, HPV DNA positive and negative groups, respectively. Results 　In the total of 13024 subjects, 1687 (12. 95 %) smears were found with t richomonas. There was no statistically significant difference in rates of t richomonas between in women with HR-HPV DNA positive and negative ( P >0. 05) . But the rate was significantly higher in women with negative cytological diagnosis than in women with squamous int raepithelial lesions ( P > 0. 05) . Women who had negative biopsy had a significantly higher t richomonas rate compared with women who had ≥CIN2 ( P < 0. 05) . Conclusion 　The presence of trichomonas had no association with HR-HPV infection, neither increased the risk of having cervical carcinoma.