Teh Concentrations of ET-1 in the Plasma and the Tissues of Patients with Stomach and Esophagus Cancer were Measured

Objective To investigate the effect of endothelin on the digestive tract tumor,Methods the plasma and tissues levels of endothelin (ET) were determined by RIA in 19 cases of stomach cancer and 10 case of esophagus cancer. Results The results revealed that the ET-1 levels in the cancer tissues were increased (57.41±29.41).The concentrations of ET-1 in plasma were significantly higher in stomach cancer group and esophagus cancer group,27.01±5.95 and 27.45±6.24 respectively,than in control group,but the plasma ET-1 levels were not different in every cell type.Condusion These results suggest that ET-1 may be involved in the occurrence and development of tumor.These will supply a clue for further study of the effect of ET-1 on digestive tract tumor.