Study on the action mode of morphogenetic PROTEIN-2 inhibiting glioma cells

Objective To investigate the action mode of bone morphogenetic protein-2 (BMP-2) inhibiting glioma cell. Methods We incubated cultured human SHG-44 glioma cell with recombinated bone morphogenetic protein-2 (rhBMP-2) protein. Cell growth curve was characterized. Cell cycle and Annexin V staining were detected by flow cytometry for studing the action mode of rhBMP-2. Results The DNA content of SHG44 increased in G1cycle, and decreased in S cycle obviously ( P <0.01)in groups incubated with rhBM...