The analysis of telomere length in acute myelogenous leukaemia

LIU Li; SUN Bing-zhong; LIANG Ying-min; et al

doi:10.3971/j.issn.1000-8578.3225

LIU Li, SUN Bing-zhong, LIANG Ying-min, et al, . The analysis of telomere length in acute myelogenous leukaemia[J]. Cancer Research on Prevention and Treatment, 2002, 29(03): 192-193. DOI: 10.3971/j.issn.1000-8578.3225

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The analysis of telomere length in acute myelogenous leukaemia

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Objective To study the changes and significance of telomere lenghth in acute myelogenous leukaemia. Methods The method of Southern hybridization was used to estimate the length of telomere. Results Mean terminal restriction fragments (TRF) length of AML (7.6±2.1 kb) was significantly shorter than that of normal control(9.3±1.9 kb). Conclusion It suggests that the lose of telomere is a important change of genetics of AML in the process of malignant transformation .It may lead to chromosomal instability a...

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The analysis of telomere length in acute myelogenous leukaemia

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