The Study of Relationship between Inactivation of Tumor Suppressor Gene Cluster Located in Chromosome 9p21 and Progression of Extra-hepatic Bile Duct Cancer

Objective To study the abnormal expression of three tumor suppressor p14/ARF, p15/INK4B and p16/INK4A located in chromosome 9p21 in the tissue of extra-hepatic bile duct cancer, and to discuss the possible role of these three genes in the initiation and progression of bile duct cancer. Methods The expression of p14, p15 and p16 proteins in the tissues of tumor, tumor side and cholangitis were studied using the method of immunohistochemistry. Results The rates of p14/ARF and p16/INK4A gene expression loss ...