Role of Urokinase-type Plasminogen Activator and Vascular Endothelial Growth Factor and the Correlation in Human Astrocytomas Invasion

Objective To investigate the expression features and clinical significance of urokinse-type plasminageon activator and vascular endothelial growth factor (uPA) in human astrocytomas. Methods We retrospectively studied the presence and distribution of uPA and VEGF protein by immunohistochemical method in 64 cases of human brain astrocytomas、4 cases of pituitary adenoma、5 cases of normal brain tissue.Their relation to clinical data was also comparatively analyzed. Results All astrocytomas expressed uPA and V...